Comparison between major scanners on detection of new threats identified by the Malware Incident Reporting & Termination (MIRT) team.
The results are the very good new threat detection rate of AntiVir and the relatively poor performance of AVG and Avast! with Kaspersky and NOD32 falling in the middle.
Almost all have poor performance in detecting new threats that maybe is saying that you no longer can rely exclusively on signature based anti malware products to protect you from the current onslaught of new threats.
More info:
http://techsupportalert.com/issues/issue144.htm#Section_0
and
http://winnow.oitc.com/malewarestats.php