Click to run is slowing down things, so yes it must be disabled and no it will not prevent applications from running.
It depends where you put them and what settings there are in CleanUp
There will be a little performance, but the question is always if you notice it or not.
e.g. 100km/h is slower than 100,05km/h, but you likely will not notice the difference although there sure is.
But as I’ve said many times, there is no “cleanup” tool that does anything you can’t do already yourself.
I.m.o. they are all a waste of money (if you have to pay for them)
Click to run is most definitely required to run MS Office apps - well certainly Excel which would not start until I manually re-enabled and started the service. Befores that I tries repair teh installation but that failed and reported that it failed becaise that service was disable.
I do agree that it’s a waste of money though and I won’t be buying it.
as for these images of letters I can hardly read them at all