I want a good thorough scan and I don’t want to waste resources either.
Then just run the default Full System Scan.
Assuming you’re not constantly installing and uninstalling apps, so that the cache is always having to update, I’ve found that keeping the persistent cache active makes a huge difference in improving scan times. The first time you use it, a scan will take much longer because of having to populate the cache, but once that’s been done, on my system a full system scan including default archive types now takes about half the time it took under 4.8 to do an equivalent scan without archives.