I’m just trialing the tools right now. There is a particular piece of PUP that we actively need, however we do not wish to disable PUP detection generically.
I have read you’re guidance and understand why you designate the tool as PUP, but its needed and this is the way 
Is it possible to whitelist a single specific PUP ruleset? Designating a path as ‘do not check’ isn’t an attractive option.
Thanks
It rather depends where the problem exists - e.g. are getting an Avast Alert and if so which Avast Shield, commonly this would be either the File System Shield or the Web Shield.
So attaching a screenshot of the alert window (with more Details selected) or blocking would help.
Attaching Images to your post - When you Click the Reply button it opens a text window for you to post your comment (reply or post).
Click the Preview button, that shows what you have input and expands it to include ‘Attachments and other options’. Click that it further expands, here you can attach images, etc. at the bottom of your post.
See my attached image, click to expand.